Synthesis of the first unnatural schisantherins and their effects in multidrug-resistant cancer cells

Authors :: Schobert, Rainer
Kern, Werner
Milius, Wolfgang
Ackermann, Tamara
Zoldakova, Miroslava
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2008, Vol. 49 Issue 21, p3359-3362. 4p.
Publication Year :: 2008
Abstract: Abstract: Schisandrol A, a dibenzocyclooctadiene lignan, was obtained by a simplified procedure from Schisandra chinensis fruits. Its reaction with carboxylic acids to give new esters (schisantherins) required special conditions such as microwave irradiation. An X-ray single crystal structure analysis of schisandrol A revealed a sterical shielding of the secondary OH group as the likely reason. The cinnamoate inhibited the P-gp drug transporters of multidrug-resistant human Kb-V1 cervix carcinoma cells better than the natural benzoate and comparable to the clinical sensitizer verapamil. [Copyright &y& Elsevier]

Language :: English
ISSN :: 00404039
Volume :: 49
Issue :: 21
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 31916451
Full Text :: https://doi.org/10.1016/j.tetlet.2008.03.134

Full Text Access

Tools