Back to Search Start Over

NF-κB Regulates Prenatal Stress-Induced Cognitive Impairment in Offspring Rats.

Authors :
Hui Li
Ning Jia
Zhuanli Bai
Rui Chen
Tianbao Song
Xia Li
Qing Cai
Zhongliang Zhu
Jiankang Liu
Source :
Behavioral Neuroscience. Apr2008, Vol. 122 Issue 2, p331-339. 9p. 4 Diagrams, 4 Charts, 7 Graphs.
Publication Year :
2008

Abstract

The study was designed to investigate whether nuclear factor of kappa B (NF -κB) plays regulating role in prenatal stress-induced cognitive impairment and oxidative damage in offspring rats. The authors used a rat model to study plasma levels of corticosterone and oxidative DNA damage (8-OH-dG), protein expression of P65/p50 NF-κB, and cognitive function in female and male offspring rats in middle pregnant stage and later pregnant stage. Prenatal stress affected the capability of learning and memory in the offspring, especially in later stage stressed female offspring. The levels of corticosterone and 8-OH-dG were enhanced in response to stress. Both middle and later stage stresses induced a significant decrease in P65 expression and a significant increase in P50 expression in female offspring. In addition, later stage stress induced a significant decrease in P50 expression in male offspring. These results suggest that NF --κB complex may be acting in a positive regulatory fashion in prenatal stress--induced cognitive impairment and that oxidative DNA damage may exacerbate the activation of NF --κKB. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07357044
Volume :
122
Issue :
2
Database :
Academic Search Index
Journal :
Behavioral Neuroscience
Publication Type :
Academic Journal
Accession number :
31807255
Full Text :
https://doi.org/10.1037/0735-7044.122.2.331