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Modeling tyrosinase activity. Effect of ligand topology on aromatic ring hydroxylation: An overview

Authors :
De, Anindita
Mandal, Sukanta
Mukherjee, Rabindranath
Source :
Journal of Inorganic Biochemistry. May2008, Vol. 102 Issue 5/6, p1170-1189. 20p.
Publication Year :
2008

Abstract

Abstract: Synthetic modeling of tyrosinase (o-phenol ring hydroxylation) has emerged as a novel class of successful biomimetic studies. It is a well-established fact that the reaction of dioxygen with copper(I) complexes of m-xylyl-based ligands generate putative copper–oxygen intermediate species such as side-on peroxo {CuII 2(μ-O2)}2+ [in some cases bis-oxo in equilibrium with isomeric side-on peroxo], due to oxygen activation. Electrophilic attack of such species brings about monooxygenase activity by incorporating one of the oxygens to m-xylyl ring of the ligand and the other oxygen is reduced to hydroxide ion. The goal of this review is to provide a concise overview of the present day knowledge in this field of research to emphasize the important role the designed ligands play in eliciting the desired tyrosinase-like chemistry. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01620134
Volume :
102
Issue :
5/6
Database :
Academic Search Index
Journal :
Journal of Inorganic Biochemistry
Publication Type :
Academic Journal
Accession number :
31750829
Full Text :
https://doi.org/10.1016/j.jinorgbio.2008.01.030