Use of Metformin in Polycystic Ovary Syndrome: A Meta-Analysis.

The article studies the efficacy of metformin, used either alone or in combination with clomiphene citrate, in women with polycystic ovary syndrome (PCOS) by examining ovulation, pregnancy and live birth. The authors also examine sources of heterogeneity among the published randomized controlled trials in terms of study quality, design and patient characteristics. They note that metformin alone improves the odds of ovulation, but does not seem to be useful in achieving a clinical pregnancy.