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Small-Molecule Fluorophores To Detect Cell-State Switching in the Context of High-Throughput Screening.
- Source :
-
Journal of the American Chemical Society . 4/2/2008, Vol. 130 Issue 13, p4208-4209. 2p. 2 Graphs. - Publication Year :
- 2008
-
Abstract
- The article focuses on the use of small molecule fluorophores in detecting cell-state switching in high-throughput screening. It discusses the treatment of the myoblasts and myotubes with a dilution of original compounds that was achieved by serial dilutions, and usage of E26 in cell-based screening for muscle differentiation inhibitors. Results suggest E26 can be used in cell-based screening for myogenesis which can be achieved by binding to a certain protein in a myotube state.
- Subjects :
- *MYOBLASTS
*MYOGENESIS
*PROTEINS
*FLUORESCENCE
*MUSCLE cells
*CELL differentiation
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 130
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 31648137
- Full Text :
- https://doi.org/10.1021/ja077656d