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Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2008, Vol. 18 Issue 7, p2292-2295. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1λ6-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines. [Copyright &y& Elsevier]
- Subjects :
- *CYCLIN-dependent kinases
*PROTEIN kinases
*CANCER cells
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 31581423
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.03.002