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Technical note: The calibration of 90Y-labeled SIR-Spheres® using a nondestructive spectroscopic assay.

Authors :
Selwyn, R.
Micka, J.
DeWerd, L.
Nickles, R.
Thomadsen, B.
Source :
Medical Physics. Apr2008, Vol. 35 Issue 4, p1278-1279. 2p.
Publication Year :
2008

Abstract

90Y-labeled SIR-Spheres® are currently used to treat patients with hepatic metastases secondary to colorectal adenocarcinoma. In general, the prescribed activity is based on empirical data collected during clinical trials. The activity of the source vial is labeled by the manufacturer as 3.0 GBq±10% and is not independently verified by the end user. This technical note shows that the results of a nondestructive spectroscopic assay of a SIR-Spheres® sample was 26% higher than the activity stated by the manufacturer. This difference should not impact the current empirical prescription method but may be problematic for patient-specific dosimetry applications, such as image-based dosimetry. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00942405
Volume :
35
Issue :
4
Database :
Academic Search Index
Journal :
Medical Physics
Publication Type :
Academic Journal
Accession number :
31521129
Full Text :
https://doi.org/10.1118/1.2889621