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State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells
- Source :
-
Neuron . Mar2008, Vol. 57 Issue 6, p905-916. 12p. - Publication Year :
- 2008
-
Abstract
- Summary: Cortical pyramidal neurons alter their responses to input signals depending on behavioral state. We investigated whether changes in somatic inhibition contribute to these alterations. In layer 5 pyramidal neurons of rat visual cortex, repetitive firing from a depolarized membrane potential, which typically occurs during arousal, produced long-lasting depression of somatic inhibition. In contrast, slow membrane oscillations with firing in the depolarized phase, which typically occurs during slow-wave sleep, produced long-lasting potentiation. The depression is mediated by L-type Ca2+ channels and GABAA receptor endocytosis, whereas potentiation is mediated by R-type Ca2+ channels and receptor exocytosis. It is likely that the direction of modification is mainly dependent on the ratio of R- and L-type Ca2+ channel activation. Furthermore, somatic inhibition was stronger in slices prepared from rats during slow-wave sleep than arousal. This bidirectional modification of somatic inhibition may alter pyramidal neuron responsiveness in accordance with behavioral state. [Copyright &y& Elsevier]
- Subjects :
- *NEURONS
*VISUAL cortex
*MENTAL depression
*LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 08966273
- Volume :
- 57
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 31400841
- Full Text :
- https://doi.org/10.1016/j.neuron.2008.01.030