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Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2008, Vol. 18 Issue 4, p1413-1418. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: 5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure–activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compounds are discussed. [Copyright &y& Elsevier]
- Subjects :
- *NUCLEIC acids
*VIRAL hepatitis
*RNA polymerases
*HEPATITIS C
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 29958811
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.01.007