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A surface-enhanced Raman spectroscopy substrate for highly sensitive label-free immunoassay.
- Source :
-
Applied Physics Letters . 1/28/2008, Vol. 92 Issue 4, p043116. 3p. 1 Diagram, 1 Chart, 2 Graphs. - Publication Year :
- 2008
-
Abstract
- Large-scale uniform silicon nanowires (SiNWs) array was fabricated by chemical etching on n-Si(111) wafer. Silver nanoparticles (AgNPs) were loaded on their surfaces. The AgNPs on SiNWs (AgNPs@SiNWs) array exhibit strong surface-enhanced Raman effect. On the substrate surfaces, characteristic Raman signals are generated with trace amount of mouse immunoglobulin G (mIgG), goat-anti-mouse immunoglobulin G (gamIgG), and immune complexes formed from 4 ng each of mIgG and gamIgG. The shifted positions and changed intensities in Raman bands indicate the occurrence of immunoreactions. This AgNPs@SiNWs array is a unique substrate for surface-enhanced Raman spectroscopy to show the immune reagents and immunoreactions at higher sensitivity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RAMAN spectroscopy
*IMMUNOASSAY
*NANOWIRES
*SILICON
*SILVER
*NANOPARTICLES
Subjects
Details
- Language :
- English
- ISSN :
- 00036951
- Volume :
- 92
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Applied Physics Letters
- Publication Type :
- Academic Journal
- Accession number :
- 29401123
- Full Text :
- https://doi.org/10.1063/1.2833695