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Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides
- Source :
-
Bioorganic & Medicinal Chemistry . Feb2008, Vol. 16 Issue 3, p1400-1424. 25p. - Publication Year :
- 2008
-
Abstract
- Abstract: An efficient and facile synthesis of a large series of diverse 6-[2-(dialkylamino)vinyl]-, 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, and 6-[2-(alkylsulfanyl)ethyl]purine nucleosides (35 examples of both ribo- and 2′-deoxyribonucleosides) was developed. The key transformations involved conjugate nucleophilic additions of amines, alcoholates, or thiolates to Tol-protected 6-alkylylpurine or 6-vinylpurine nucleosides. 6-[(2-Dialkylamino)vinyl]- and some 6-[(2-dialkylamino)ethyl]purine ribonucleosides exerted significant cytostatic effects and some anti-HCV activity with low selectivity. [Copyright &y& Elsevier]
- Subjects :
- *URIC acid
*NUCLEOSIDES
*NUCLEOTIDES
*ORGANIC compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29380876
- Full Text :
- https://doi.org/10.1016/j.bmc.2007.10.063