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Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2008, Vol. 18 Issue 3, p1116-1119. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: Modified purine analogs of GS-9148 [5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (2′-Fd4AP) were synthesized and their anti-HIV potency evaluated. The antiviral activity of guanosine analog (2′-Fd4GP) was comparable that of to 2′-Fd4AP in MT-2 cells, but selectivity was reduced. [Copyright &y& Elsevier]
- Subjects :
- *PURINES
*PHOSPHONIC acids
*HIV
*ANTIVIRAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 29376463
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.11.126