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Inflammatory osteoclastogenesis can be induced by GM-CSF and activated under TNF immunity
- Source :
-
Biochemical & Biophysical Research Communications . Mar2008, Vol. 367 Issue 4, p881-887. 7p. - Publication Year :
- 2008
-
Abstract
- Abstract: In inflammatory arthritis such as RA, osteoclastic activity is severely enhanced. GM-CSF was reportedly elevated in synovial fluid, but is a strong inhibitor of osteoclastogenesis; here lies a contradiction. Our objective was to examine what type of osteoclasts generate and resorb bone with resistance to GM-CSF in an inflammatory joint. Monocyte-derived cells generated in GM-CSF were morphologically and immunophenotypically different from both the conventional DC and macrophage. They could differentiate into osteoclasts in the presence of RANKL + M-CSF, acquiring a stronger osteoclastic activity under TNF treatment. Furthermore, their differentiation was not inhibited by GM-CSF, while monocyte-derived osteoclast differentiation was completely inhibited. The resorption was suppressed by GM-CSF, and the existence of another osteoclastic pathway has been suggested. Our findings indicate another type of osteoclast exists in inflammatory arthritis. [Copyright &y& Elsevier]
- Subjects :
- *CEREBROSPINAL fluid
*ARTHRITIS
*JOINT diseases
*RHEUMATOID arthritis
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 367
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 29370044
- Full Text :
- https://doi.org/10.1016/j.bbrc.2008.01.023