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Novel phenotypic markers and screening score for the metabolic syndrome in adult Asian Indians
- Source :
-
Diabetes Research & Clinical Practice . Feb2008, Vol. 79 Issue 2, pe1-e5. 0p. - Publication Year :
- 2008
-
Abstract
- Abstract: Aims: The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are common in Asian Indians. Simple yet reliable phenotypic markers are needed for early detection of the MS in Asian Indians. Methods: In this cross-sectional study, 126 subjects either with of without the MS were compared. Anthropometric measurements (including assessment of novel phenotypic markers) and metabolic profile were done. Results: On univariate analysis, age more than 35 year, female gender, presence of buffalo hump and double chin and family history of T2DM were significantly associated with the MS. A metabolic syndrome screening (MSS) score (1.0×double chin+1.2×buffalo hump+1.3×gender+1.4×age category) was generated with a cutoff value of 3.5 out of total points of 4.9, with sensitivity and specificity 82% and 71% [area under the curve=0.83; 95% confidence Interval (0.76–0.90)], respectively in detecting individuals with the MS. Conclusion: We describe buffalo hump and double chin as novel phenotypic markers for detection of MS for the first time. The MSS score generated by us may be a useful tool for detection of MS in adult Asian Indians; however, it needs further validation in a larger sample of Asian Indians and in other ethnic groups. [Copyright &y& Elsevier]
- Subjects :
- *TYPE 2 diabetes
*INSULIN resistance
*DISEASES
*DRUG resistance
Subjects
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 79
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 28830462
- Full Text :
- https://doi.org/10.1016/j.diabres.2007.08.002