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Ghrelin: A multifunctional hormone in non-mammalian vertebrates
- Source :
-
Comparative Biochemistry & Physiology Part A: Molecular & Integrative Physiology . Feb2008, Vol. 149 Issue 2, p109-128. 20p. - Publication Year :
- 2008
-
Abstract
- Abstract: In mammals, ghrelin is a non-amidated peptide hormone, existing in both acylated and non-acylated forms, produced mainly from the X/A or ghrelin cells present in the mucosal layer of the stomach. Ghrelin is a natural ligand of the growth hormone (GH) secretagogue-receptor (GHS-R), and functions primarily as a GH-releasing hormone and an orexigen, as well as having several other biological actions. Among non-mammalian vertebrates, amino acid sequence of ghrelin has been reported in two species of cartilaginous fish, seven species of teleosts, two species of amphibians, one species of reptile and six species of birds. The structure and functions of ghrelin are highly conserved among vertebrates. This review presents a concise overview of ghrelin biology in non-mammalian vertebrates. [Copyright &y& Elsevier]
- Subjects :
- *GHRELIN
*AMINO acid sequence
*PEPTIDE hormones
*VERTEBRATES
Subjects
Details
- Language :
- English
- ISSN :
- 10956433
- Volume :
- 149
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Comparative Biochemistry & Physiology Part A: Molecular & Integrative Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 28803200
- Full Text :
- https://doi.org/10.1016/j.cbpa.2007.12.004