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Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jan2008, Vol. 18 Issue 2, p821-824. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: γ-Lactam analogs (2) of EP4 receptor agonists were identified by substitution of the pyrazolidinone ring (1) with a pyrrolidinone ring. Several compounds (such as 2a, 2h) with high potency, selectivity and acceptable PK profiles were discovered. These were assessed in animal models of ovulation induction and bronchoconstriction. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 28611880
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.11.020