Back to Search
Start Over
β-Melanocyte-Stimulating Hormone Potently Reduces Appetite Via the Hypothalamus in Chicks.
- Source :
-
Journal of Neuroendocrinology . Feb2008, Vol. 20 Issue 2, p220-226. 7p. 1 Chart, 6 Graphs. - Publication Year :
- 2008
-
Abstract
- The melanocortin system together with other appetite-related systems plays a significant role in appetite regulation. The appetite-related effects of one such melanocortin, β-melanocyte-stimulating hormone (MSH), are well documented in rodents; however, its effects in the avian class are not thoroughly understood. Thus, we designed a study to determine the effects of i.c.v. β-MSH injection on food and water intake, plasma corticosterone concentration, ingestive and non-ingestive behaviours, and hypothalamic neuronal activation using Cobb-500 chicks. Chicks responded to β-MSH-treatment with a reduction in food and water intake; however when water intake was measured independently of food intake, it was not affected. β-MSH-treated chicks also had increased plasma corticosterone concentrations and increased c-Fos reactivity in the periventricular, paraventricular and infundibular nuclei, and the ventromedial hypothalamus; however, the lateral hypothalamus was not affected. The effect on food intake is primary because behaviours that may be competitive with food intake were not increased in β-MSH-treated chicks. Based on these results, we conclude that β-MSH causes anorexigenic effects that are likely primarily mediated via stimulation of satiety-related hypothalamic nuclei in broiler-type chicks. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MELANOCYTES
*PEPTIDE hormones
*HYPOTHALAMUS
*ENDOCRINE glands
*APPETITE
Subjects
Details
- Language :
- English
- ISSN :
- 09538194
- Volume :
- 20
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 28542680
- Full Text :
- https://doi.org/10.1111/j.1365-2826.2007.01639.x