Synthesis of the C1–C12 fragment of the tedanolides. Selective hydroboration–protonation of allylic alcohol approach

Authors :: Jung, Michael E.
Yoo, Dongwon
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jan2008, Vol. 49 Issue 5, p816-819. 4p.
Publication Year :: 2008
Abstract: Abstract: The combination of highly stereoselective vinyllithium addition and hydroboration–protonation of the resulting allylic alcohol permits the preparation of the completely protected C1–C12 fragment 2 of the novel macrocyclic cytotoxic agent tedanolide 1. [Copyright &y& Elsevier]

Subjects :: *CHEMICAL reduction
*ALCOHOLS (Chemical class)
*CHEMICAL reactions
*TETRAHEDRA

Language :: English
ISSN :: 00404039
Volume :: 49
Issue :: 5
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 28148834
Full Text :: https://doi.org/10.1016/j.tetlet.2007.11.181

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