The voltage-gated Na+ channel NavBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4.

The article provides information on voltage-gated Na+ channel NavBP when it localizes with methyl accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. It notes that Nav , found in alkaliphilic Bacillus pseudofirmus OF4, is a member of the bacterial voltage-gated Na+ channel superfamily. NavBP is needed by alkaliphile during the normal chemotaxis responses and for optimal pH homeostasis during a shift to alkaline conditions of suboptimally low Na+ concentrations. Interaction of NavBP with one or more other proteins in vivo, specially methyl-accepting chemotaxis protein (MCP) is involved in the activation of the channel under the pH conditions existing in extremophile.