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An Extension of the Regression of Offspring on Mid-Parent to Test for Association and Estimate Locus-Specific Heritability: The Revised ROMP Method.
- Source :
-
Annals of Human Genetics . Jan2008, Vol. 72 Issue 1, p115-125. 11p. 2 Charts, 2 Graphs. - Publication Year :
- 2008
-
Abstract
- The Regression of Offspring on Mid-Parent (ROMP) method is a test of association between a quantitative trait and a candidate locus. ROMP estimates the trait heritability and the heritability attributable to a locus and requires genotyping the offspring only. In this study, the theory underlying ROMP was revised (ROMPrev) and extended. Computer simulations were used to determine the type I error and power of the test of association, and the accuracy of the locus-specific heritability estimate. The ROMPrev test had good power at the 5% significance level with properly controlled type I error. Locus-specific heritability estimates were, on average, close to simulated values. For non-zero locus-specific heritability, the proposed standard error was downwardly biased, yielding reduced coverage of 95% confidence intervals. A bootstrap approach with proper coverage is suggested as a second step for loci of interest. ROMPrev was applied to a study of cardiovascular-related traits to illustrate its use. An association between polymorphisms within the fibrinogen gene cluster and plasma fibrinogen was detected (p < 0.005) that accounted for 29% of the estimated fibrinogen heritability. The ROMPrev method provides a computationally fast and simple way of testing for association and obtaining accurate estimates of locus-specific heritability while minimizing the genotyping required. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00034800
- Volume :
- 72
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annals of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 28081408
- Full Text :
- https://doi.org/10.1111/j.1469-1809.2007.00401.x