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Repeat transarterial chemoembolization (TACE) for progressive hepatic carcinoid metastases provides results similar to first TACE.
- Source :
-
Journal of Gastrointestinal Surgery . Dec2007, Vol. 11 Issue 12, p1680-1685. 6p. 2 Charts, 1 Graph. - Publication Year :
- 2007
-
Abstract
- <bold>Background: </bold>Transarterial chemoembolization (TACE) is commonly used to treat metastatic carcinoid tumors; however, the management of progressive disease is less clear. We sought to determine if patients with disease progression after TACE would benefit from repeat TACE.<bold>Methods: </bold>The records of 27 patients undergoing repeat TACE for radiologic or symptomatic progression after TACE for metastatic carcinoid were reviewed and compared to 122 undergoing first TACE. Overall and progression-free survivals were estimated by the Kaplan-Meier method.<bold>Results: </bold>Mean disease-free interval after first TACE was 11.8 months. Radiologic response was observed in 61% compared to 82% after first TACE (p=0.058); hormone response in 64% compared to 80% (p=0.159); and symptomatic response in 77% compared to 92% (p=0.053). The complication rate after repeat TACE was lower than after first TACE (p=0.03). Median overall survival was similar after repeat (28.1 months) and first TACE (33.3 months) (p=0.53). Progression-free survival was shorter after repeat TACE but not significantly so. No factor examined could predict survival after repeat TACE.<bold>Conclusion: </bold>Repeat TACE for patients with hepatic carcinoid metastases failing first TACE or having evidence of disease progression is safe and offers a viable treatment option. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1091255X
- Volume :
- 11
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Gastrointestinal Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 28036693
- Full Text :
- https://doi.org/10.1007/s11605-007-0235-7