Comparison of different near-infrared spectroscopic cerebral oxygenation indices with central venous and jugular venous oxygenation saturation in children.

Background: We compared two different near-infrared spectrophotometers: cerebral tissue oxygenation index (TOI) measured by NIRO 200 and regional cerebral oxygenation index (rSO2) measured by INVOS 5100 with venous oxygen saturation in the jugular bulb (SjO2) and central SvO2 from the superior caval vein (SVC) during elective cardiac catheterization in children. Methods: A prospective observational clinical study in 31 children with congenital heart defects in a catheterization laboratory was undertaken. TOI was compared with SjO2 in the left jugular bulb and with SvO2. rSO2 was compared with SjO2 from the right jugular bulb and SvO2. Linear regression analysis and Pearson’s correlation coefficient were calculated and Bland–Altman analyses were performed. Results: Cerebral TOI and SjO2 were significantly correlated ( r = 0.56, P < 0.0001), as well as TOI and SvO2 with r = 0.74 ( P < 0.0001). Bland–Altman plots showed a mean bias of −4.3% with limits of agreement of 15.7% and −24.3% for TOI and SjO2 and a mean bias of −4.9% with limits of agreement of 10.3% and −20.1% for TOI and SvO2. Cerebral rSO2 and SjO2 showed a significant correlation ( r = 0.83, P < 0.0001) and rSO2 and SvO2 showed excellent correlation with r = 0.93 ( P < 0.0001). Bland–Altman plots showed a mean bias of −5.2% with limits of agreement of between 8.4% and −18.8% for rSO2 and SjO2 and a mean bias of 5.6% with limits of agreement of 13.4% and −2.2% for rSO2 and SvO2. Conclusions: Both near-infrared spectroscopy devices demonstrate a significant correlation with SjO2 and SvO2 values; nevertheless both devices demonstrate a substantial bias of the measurements to both SjO2 and SvO2. [ABSTRACT FROM AUTHOR]