Comparison of Child-Turcotte-Pugh and Pediatric End-Stage Liver Disease Scoring Systems to Predict Morbidity and Mortality of Children Awaiting Liver Transplantation

Abstract: Background: The pediatric end-stage liver disease (PELD) scoring system has been used widely for prioritizing children awaiting orthotopic liver transplantation (OLT). The aim of the present study was to compare the Child-Turcotte-Pugh scoring system with PELD to predict morbidity and mortality of children scheduled for OLT before the organ was available. Materials and Methods: From 1999 to 2006, 83 infants and children were evaluated and scheduled for OLT. Child and PELD scores were determined according to the initial assessment at the time of listing. Outcome was examined using records and follow-up data. Results: Among 83 patients, 12% were Child A; 53%, Child B; and 35%, Child C. The mean PELD score at listing was 19.8 ± 12.8. Patients with Child scores A, B, and C displayed mean PELD scores of 7.1 ± 4.9, 15.7 ± 9.3, and 30.5 ± 11.7, respectively. Child classification and scoring showed a positive correlation with the PELD score (Spearman’s correlation coefficient: 0.666, P = .001). A higher PELD score was associated with greater morbidity and mortality. Conclusion: Child classification has several shortcomings; therefore, PELD scores appear to be the best metric to prioritize children listed for OLT. [Copyright &y& Elsevier]