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Delivery of Doxorubicin from Biodegradable PEG Hydrogels Having Schiff Base Linkages.
- Source :
-
Journal of Bioactive & Compatible Polymers . Nov2007, Vol. 22 Issue 6, p589-601. 13p. 3 Diagrams, 1 Chart, 5 Graphs. - Publication Year :
- 2007
-
Abstract
- In our quest to develop new drug delivery systems, we designed and synthesized PEG-conjugates and PEG-hydrogels with a degradable linkage to the drug. Specifically, methoxyPEG-doxorubicin (MPEG-CH=N-Doxo) and doxorubicin-PEG aldehyde (OHC-PEG-CH=N-Doxo) conjugates, plus poly (vinyl amine)-PEG-doxorubicin (PVAm-PEG-Doxo) hydrogels were prepared. The hydrogels were crosslinked by PEG-Schiff base linkages, and the Doxo was conjugated to the gel by pendant Schiff base bonds (PVAm-N=CH-PEG-CH=N- Doxo). The release profile of Doxo from the hydrogels was dependent on pH and on the ratio of PVAm to the PEG-dialdehyde crosslinker. These degradable PEG hydrogels could be good candidates for slow release of Doxo from subcutaneous or IM implants. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08839115
- Volume :
- 22
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Bioactive & Compatible Polymers
- Publication Type :
- Academic Journal
- Accession number :
- 27868523
- Full Text :
- https://doi.org/10.1177/0883911507084653