Back to Search
Start Over
Serum cortisol and thyroxine concentrations as predictors of death in critically ill puppies with parvoviral diarrhea.
- Source :
-
Journal of the American Veterinary Medical Association . 11/15/2007, Vol. 231 Issue 10, p1534-1539. 6p. - Publication Year :
- 2007
-
Abstract
- Objective-To evaluate the role of adrenal and thyroid hormones in the prediction of death in a population of critically ill puppies with parvoviral diarrhea by measuring serial daily serum concentrations of cortisol and thyroxine. Design-Prospective case-control study Animals-57 critically ill puppies with parvoviral diarrhea admitted to the hospital and 17 clinically normal control puppies. Procedures-Basal serum cortisol and thyroxine concentrations were measured for each dog with parvoviral diarrhea at admission (prior to treatment) and daily until death, euthanasia, or discharge. Results-Median time between admission and death was 48 hours (ie, on day 3). Median serum cortisol concentration on day 1 (admission) in all dogs with parvoviral diarrhea (248 nmol/L) was significantly higher than in control dogs (77 nmol/L). No significant difference was found in the day 1 median serum cortisol concentration of 11 dogs that died (302 nmol/L) and 46 dogs that survived (238 nmol/L). A significantly higher median serum cortisol concentration was, however, found in nonsurvivor group dogs, compared with survivor group dogs, on days 2 and 3. Median serum thyroxine concentration on day 1 in dogs with parvoviral diarrhea was significantly lower than in control dogs (8.12 nmol/L vs 35 nmol/L, respectively). Median serum thyroxine concentration of nonsurvivor group dogs (4.4 nmol/ L) was significantly lower than that of survivor group dogs (9.2 nmol/L) at admission and became even lower on days 2 and 3. Conclusions and Clinical Relevance-High serum cortisol and low serum thyroxine concentrations at 24 and 48 hours after admission were associated with death in dogs with parvoviral diarrhea. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00031488
- Volume :
- 231
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 27782744
- Full Text :
- https://doi.org/10.2460/javma.231.10.1534