Genomic Deletion Marking an Emerging Subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula.

Authors :: Dempsey, M. P.
Dobson, M.
Zhang, C.
Zhang, M.
Lion, C.
Gutiérrez-Martín, C. B.
Iwen, P. C.
Fey, P. D.
Olson, M. E.
Niemeyer, D.
Francesconi, S.
Crawford, R.
Stanley, M.
Rhodes, J.
Wagner, D. M.
Vogler, A. J.
Birdsell, D.
Keim, P.
Johansson, A.
Hinrichs, S H.
Source :: Applied & Environmental Microbiology. Nov2007, Vol. 73 Issue 22, p7465-7470. 6p. 5 Diagrams.
Publication Year :: 2007
Abstract: Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula. [ABSTRACT FROM AUTHOR]

Subjects :: *FRANCISELLA tularensis
*GRAM-negative bacteria
*GENETIC polymorphisms
*GENETICS

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