Back to Search
Start Over
Rapid Identification of Immunostimulatory α-Galactosylceramides Using Synthetic Combinatorial Libraries.
- Source :
-
Journal of Combinatorial Chemistry . Sep2007, Vol. 9 Issue 6, p1084-1093. 10p. - Publication Year :
- 2007
-
Abstract
- Two 60+-membered libraries of α-galactosylceramides have been prepared by reactions between activated ester resins and two core, fully deprotected galactosylated sphingoid bases. The libraries were evaluated for their ability to stimulate CD1d-restricted NKT cells, using in vitro stimulation of a murine NKT cell hybridoma line and for their ability to induce the expansion of NKT cells from peripheral blood mononuclear cells (PBMC) of a normal human subject. Our results showed that many compounds constructed on a C18-phytosphingosine base had significant stimulatory activity in both assays. Because no product purification was required, this approach is particularly attractive as a method for rapid synthesis of large libraries of potential immunomodulatory glycosylceramides. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOLOGICAL adjuvants
*COMBINATORIAL chemistry
*ORGANIC compounds
*GLYCOSYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 15204766
- Volume :
- 9
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Combinatorial Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27682602
- Full Text :
- https://doi.org/10.1021/cc070057i