Combinatorial Dapoxyl Dye Library and its Application to Site Selective Probe for Human Serum Albumin.

The combinatorial fluorescent dapoxyl dye library was prepared by both solution- and solid-phase synthesis, generating 80 unique dapoxyl derivatives. A fluorescence-based screening toward human serum albumin (HSA) found one highly sensitive HSA binder ( A41-S) with over 55-fold intensity change. Displacement assay showed the selective binding of A41-Sto the site I of HSA, addressing its potential to be a highly selective and sensitive HSA probe. [ABSTRACT FROM AUTHOR]