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Combinatorial Dapoxyl Dye Library and its Application to Site Selective Probe for Human Serum Albumin.
- Source :
-
Journal of Combinatorial Chemistry . Sep2007, Vol. 9 Issue 6, p1079-1083. 5p. - Publication Year :
- 2007
-
Abstract
- The combinatorial fluorescent dapoxyl dye library was prepared by both solution- and solid-phase synthesis, generating 80 unique dapoxyl derivatives. A fluorescence-based screening toward human serum albumin (HSA) found one highly sensitive HSA binder ( A41-S) with over 55-fold intensity change. Displacement assay showed the selective binding of A41-Sto the site I of HSA, addressing its potential to be a highly selective and sensitive HSA probe. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMICAL libraries
*SERUM
*SERUM albumin
*BLOOD proteins
Subjects
Details
- Language :
- English
- ISSN :
- 15204766
- Volume :
- 9
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Combinatorial Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27682601
- Full Text :
- https://doi.org/10.1021/cc0700546