Estudio de la microviscosidad de la hemoglobina A (HbA) y la hemoglobina S (HbS) en condiciones de desoxigenación espontánea.

The Microviscosity of hemoglobin A and hemoglobin S are analyzed in samples of intracellular concentration, during the free deoxygenation process and at 36 °C, using Glutathione and Carbonmonoxihemoglobin labeled with 4-maleimido-tempo. Labeled Glutathione shows a constant behaviour of the hemoglobin S microviscosity during the study. Labeled Carbonmonoxihemoglobin shows an increase of the microviscosity during the hemoglobin S polymerization process, which could explain the proton relaxation times behaviour determined in other articles for the same samples. Labeled Glutathione and Carbonmoxihemoglobing report constant behaviour of microviscosity in hemoglobin A. [ABSTRACT FROM AUTHOR]