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The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1
- Source :
-
Biochemical & Biophysical Research Communications . Dec2007, Vol. 364 Issue 4, p959-965. 7p. - Publication Year :
- 2007
-
Abstract
- Abstract: The CD155 ligand CD96 is an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology. [Copyright &y& Elsevier]
- Subjects :
- *IMMUNOGLOBULINS
*T cells
*MONOCLONAL antibodies
*CELL communication
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 364
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 27516291
- Full Text :
- https://doi.org/10.1016/j.bbrc.2007.10.102