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Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2007, Vol. 17 Issue 24, p6876-6878. 3p. - Publication Year :
- 2007
-
Abstract
- Abstract: A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4K) and 2,2′,2″,2‴-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After 64Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation. [Copyright &y& Elsevier]
- Subjects :
- *NEUTROPHILS
*POLYETHYLENE glycol
*POSITRON emission tomography
*LUNG diseases
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 27445228
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.10.013