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Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2007, Vol. 17 Issue 24, p6785-6789. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: A series of nucleoside phosphonate reverse transcriptase (RT) inhibitors have been synthesized and their anti-HIV activity and resistance profiles evaluated. The most potent analog [5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (d4AP) demonstrated a HIV EC50 =2.1μM, and the most favorable resistance profile against HIV-1 variants with K65R, M184V or multiple thymidine analog mutations in RT. [Copyright &y& Elsevier]
- Subjects :
- *HIV
*RIBOSE
*NUCLEOSIDES
*PHOSPHONATES
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 27445211
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.10.038