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Second-Line Combination Chemotherapy with Docetaxel for Cisplatin-Pretreated Refractory Metastatic Esophageal Cancer: A Preliminary Report of Initial Experience.
- Source :
-
Chemotherapy (0009-3157) . 2007, Vol. 53 Issue 6, p449-453. 5p. 3 Charts, 2 Graphs. - Publication Year :
- 2007
-
Abstract
- Background and Aims: Patients with esophageal cancer often develop metastatic disease after esophageal resection and generally receive cisplatin-based chemotherapy or chemoradiotherapy. The efficacy and toxicity of the combination of docetaxel, 5-fluorouracil (5-FU) and cisplatin (DFC) as a second-line chemotherapy were evaluated in patients with postoperative metastatic esophageal cancer refractory to cisplatin-based chemotherapy. Patients and Methods: Twenty patients with metastatic esophageal cancer after esophagectomy refractory to cispatin-based therapy were included in this study. The DFC regimen consisted of docetaxel (60 mg/m2) on day 1, 5-FU (500 mg/day) on days 1–5 and cisplatin (10 mg/day) on days 1–5, being repeated every 3 weeks. Results: A total of 49 cycles (median 2, range 1–6) was administered to 20 patients. The median follow-up was 8 months (range 3–24). Of the 20 patients, 1 had a complete response, 6 had a partial response, 6 had stable and 7 had progressive disease. Median time to progression for all patients was 4 months (95% Cl 1.7–5.6). The median overall survival for all patients was 8 months (95% CI 5.7–10.3). The major toxicity was myelosuppression. Neutropenia of grade 3 or more occurred in 13 patients (65%), and thrombocytopenia of grade 3 occurred in 1 patient (5%). Febrile neuropenia was observed in 1 patient (5%). There was no treatment-related mortality. Conclusion: DFC is a feasible and promising regimen as a second-line therapy in metastatic/recurrent esophageal cancer refractory to cisplatin-based chemotherapy. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESOPHAGEAL cancer
*METASTASIS
*CISPLATIN
*DRUG therapy
*FLUOROURACIL
Subjects
Details
- Language :
- English
- ISSN :
- 00093157
- Volume :
- 53
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Chemotherapy (0009-3157)
- Publication Type :
- Academic Journal
- Accession number :
- 27403733
- Full Text :
- https://doi.org/10.1159/000110018