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Genetic variation in transforming growth factor-beta1 gene associated with increased risk of esophageal squamous cell carcinoma.
- Source :
-
Tissue Antigens . Dec2007, Vol. 70 Issue 6, p464-469. 6p. 3 Charts. - Publication Year :
- 2007
-
Abstract
- The genetic alterations leading to esophageal squamous cell carcinoma (ESCC) are gradually being discovered. A wide variety of genes have been associated with ESCC development as well as tumor progression. Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine; it promotes tumor growth and metastasis in later stages of of cancer development. Variations in the DNA sequence in the TGF-β1 gene may lead to altered TGF-β1 production and/or activity, and so this can modulate an individual’s susceptibility to ESCC. To test this hypothesis, we investigated the association of the TGF-β1 gene −509 C/T and 869 T/C (Leu10Pro) polymorphisms and their haplotypes with the risk of ESCC. 247 patients with ESCC and 260 age- and sex-matched controls were studied using a polymerase chain reaction–restriction fragment length polymorphism. There were significant differences in the genotype and allele distribution of 869 T/C polymorphism of the TGF-β1 gene among cases and controls. The 869 TC and CC genotypes were associated with a significantly increased risk of ESCC as compared with the 869 TT genotypes [odds ratio (OR) = 1.882, 95% confidence interval (CI) 1.212–2.923, P = 0.005 and OR = 2.099, 95% CI 1.288–3.421, P = 0.003, respectively]. Consistent with the results of the genotyping analyses, the –509 T/869 C haplotype was associated with a significantly increased risk of ESCC as compared with the –509 C/869 T haplotype (OR = 1.463; 95% CI 1.120–1.912; P = 0.005). This study shows for the first time that TGF-β1 gene 869 T/C polymorphism may contribute to a genetic risk factor for ESCC in a Chinese population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00012815
- Volume :
- 70
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Tissue Antigens
- Publication Type :
- Academic Journal
- Accession number :
- 27373606
- Full Text :
- https://doi.org/10.1111/j.1399-0039.2007.00935.x