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A Bioinformatics Approach to Identifying Tail-Anchored Proteins in the Human Genome.
- Source :
-
Traffic . Dec2007, Vol. 8 Issue 12, p1687-1694. 8p. 1 Color Photograph, 1 Graph. - Publication Year :
- 2007
-
Abstract
- Intracellular proteins with a carboxy-terminal transmembrane domain and the amino-terminus oriented toward the cytosol are known as ‘tail-anchored’ proteins. Tail-anchored proteins have been of considerable interest because several important classes of proteins, including the vesicle-targeting/fusion proteins known as SNAREs and the apoptosis-related proteins of the Bcl-2 family, among others, utilize this unique membrane-anchoring motif. Here, we use a bioinformatic technique to develop a comprehensive list of potentially tail-anchored proteins in the human genome. Our final list contains 411 entries derived from 325 unique genes. We also analyzed both known and predicted tail-anchored proteins with respect to the amino acid composition of the transmembrane segments. This analysis revealed a distinctive composition of the membrane anchor in SNARE proteins. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEINS
*AMINO acids
*APOPTOSIS
*HUMAN genome
*HUMAN gene mapping
*BIOMOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 13989219
- Volume :
- 8
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Traffic
- Publication Type :
- Academic Journal
- Accession number :
- 27373062
- Full Text :
- https://doi.org/10.1111/j.1600-0854.2007.00661.x