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Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2007, Vol. 17 Issue 23, p6643-6646. 4p. - Publication Year :
- 2007
-
Abstract
- Abstract: Eight d-ribo-phytosphingosine derivatives were synthesized from d-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect. [Copyright &y& Elsevier]
- Subjects :
- *DEATH (Biology)
*BRAIN death
*TETRAHYDROFURAN
*CELL death
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 17
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 27353873
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.09.037