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HtrA2 and Parkinson's disease: think PINK?

Authors :
Alnemri, Emad S.
Source :
Nature Cell Biology. Nov2007, Vol. 9 Issue 11, p1227-1229. 3p. 1 Diagram.
Publication Year :
2007

Abstract

Mitochondrial dysfunction is primarily responsible for neurodegeneration in Parkinson's disease. The Parkinson's-disease-associated kinase PINK1 has been identified as an important regulator of the activity of the mitochondria-associated stress-protective protease HtrA2. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14657392
Volume :
9
Issue :
11
Database :
Academic Search Index
Journal :
Nature Cell Biology
Publication Type :
Academic Journal
Accession number :
27329001
Full Text :
https://doi.org/10.1038/ncb1107-1227