Highly diastereoselective and enantioselective direct organocatalytic anti-selective Mannich reactions employing N-tosylimines.

Organocatalytic direct anti-selective Mannich reactions of O-TBS-hydroxyacetone with various N-tosylimines derived from aromatic aldehydes in the presence of L-threonine-derived catalyst afforded 1,2-amino alcohols in good yields and with enantioselectivities of 99% in almost all cases. [ABSTRACT FROM AUTHOR]