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Deoxycholic Acid-Derived Tetraoxane Antimalarials and Antiproliferatives1.
- Source :
-
Journal of Medicinal Chemistry . Oct2007, Vol. 50 Issue 21, p5118-5127. 10p. - Publication Year :
- 2007
-
Abstract
- The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16and 25cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC5022 nM and 69 nM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PAPER
*CHOLIC acid
*ANTIMALARIALS
*DIMETHYLAMINOETHANOL
*CANCER
Subjects
Details
- Language :
- English
- ISSN :
- 00222623
- Volume :
- 50
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27037918
- Full Text :
- https://doi.org/10.1021/jm070684m