Uyku Deprivasyonunun Antioksidan Sisteme Etkisi.

Objective: It is suggested that the circadian rhythms of sleep and wakefulness might be related to oxidant/antioxidant status. It has been proposed that free radicals or oxygen reactive species produced during waking are removed during sleep. However, the effects of short and prolonged sleep deprivation on oxidant/antioxidant status in animals are on debate. The aim of this study was to determine the effect of 24 hours sleep deprivation on the oxidant/antioxidant status in blood and saliva samples. Methods: Eleven healthy nurse were chosen as the study group, blood and saliva were obtained from the nurses. In these samples, malondialdehyde (MDA), xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities were measured. Results: There were no statistically significant differences in enzyme activities and MDA levels among the samples taken after the normal sleep and before and after the sleep deprivation. Conclusion: According to the results, it was concluded that 24 hours sleep deprivation did not influence oxidant/antioxidant status in erythrocytes, plasma and saliva from the subjects. [ABSTRACT FROM AUTHOR]