Synthesis and ammonolysis of 4-acyl and 4-arylsulfonylpiperazine-2,6-diones.

A series of 4-acylated derivatives of piperazine-2,6-dione were synthesized. Ammonolysis of the synthesized piperazine-2,6-diones with aqueous ammonia led to a ring-opening reaction and the formation of corresponding iminodiacetic acid diamides with a good yield. The optimal conditions of ammonolysis were analysed. [ABSTRACT FROM AUTHOR]