Back to Search
Start Over
Effects of gamma-tocopherol supplementation on thrombotic risk factors.
- Source :
-
Asia Pacific Journal of Clinical Nutrition . Sep2007, Vol. 16 Issue 3, p422-428. 7p. 3 Charts. - Publication Year :
- 2007
-
Abstract
- Objective: The antioxidant activity of vitamin E is derived primarily from alpha-tocopherol (α-T) and gamma-tocopherol (γ-T). Results of epidemiological studies have demonstrated an inverse relationship between vitamin E intake and coronary disease. However, the results of clinical trials using α-T are equivocal. We determined the effect of 5 weeks of 100 mg/d or 200 mg/d γ-T supplementation on thrombotic markers such as platelet reactivity, lipid profile and the inflammation marker C-reactive protein (CRP). Methods and results: Fourteen healthy subjects consumed 100 mg/day while 13 consumed 200 mg/d of γ-T and 12 received placebo (soybean capsules with less than 5 mg/d γ-T) in a double-blinded parallel study design. Fasting pre and post dose blood samples were analysed. Blood γ-T concentrations increased significantly (p<0.05) relative to dose during the intervention period. Both groups receiving active ingredients showed significantly lower platelet activation after supplementation (p<0.05). Subjects consuming 100 mg/d γ-T had significantly decreased LDL cholesterol, platelet aggregation and mean platelet volume (MPV) (p<0.05). Little effect of γ-T was observed on other parameters. Conclusions: These data suggest that γ-T supplementation may have a permissive role in decreasing the risk of thrombotic events by improving lipid profile and reducing platelet activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09647058
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Asia Pacific Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 26715172