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Differences in Parapapillary Atrophy between Glaucomatous and Normal Eyes: The Beijing Eye Study
- Source :
-
American Journal of Ophthalmology . Oct2007, Vol. 144 Issue 4, p541-546. 6p. - Publication Year :
- 2007
-
Abstract
- Purpose: To determine in a population-based study whether parapapillary atrophy is associated with glaucoma. Design: Population-based cross-sectional study. Methods: The Beijing Eye Study included 4,439 of 5,324 subjects invited to participate (response rate, 83.4%). Mean age was 56.2 ± 10.6 years (range, 40 to 101 years). Color optic disk photographs (30 degrees) were examined morphometrically. Parapapillary atrophy was divided into α and β zones. Glaucomatous optic nerve atrophy was defined by a glaucomatous optic nerve head appearance. Results: After excluding highly myopic eyes, data from 4,003 (90.2%) subjects entered the statistical analysis. Glaucomatous optic nerve damage was detected in 93 (2.3%) subjects. The β zone of parapapillary atrophy as a whole and measured separately in four disk sectors was significantly larger and occurred significantly more frequently in the glaucomatous group than in the nonglaucomatous group (β zone total area, 1.21 ± 1.92 mm2 vs 0.32 ± 0.99 mm2; P < .001). In multiple regression analysis, area of β zone was significantly associated with age (P < .001), myopic refractive error (P < .001), and presence of glaucomatous optic nerve damage (P < .001), with no significant difference between chronic open-angle glaucoma (n = 72) and chronic angle-closure glaucoma (n = 21; β zone area, 1.20 ± 0.39 mm2 vs 1.19 ± 0.46 mm2; P = .69). Conclusions: In a population-based setting, the β zone of parapapillary atrophy is significantly larger and occurs more frequently in glaucomatous eyes than in normal eyes of Chinese adults, with no marked difference between chronic open-angle glaucoma and primary angle-closure glaucoma. [Copyright &y& Elsevier]
- Subjects :
- *GLAUCOMA
*MYOPIA
*OPTIC nerve diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00029394
- Volume :
- 144
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 26709849
- Full Text :
- https://doi.org/10.1016/j.ajo.2007.05.038