« Knitting a Ravelled Sleave.

The article reports on the role of epidermal growth factor receptor (EGFR) in the regulation of sleep. A study using Drosophila as a model, which was conducted to investigate the significance of EGFR, stated that the activation of EGFR ligands depends largely on the transmembrane protein Star and on Rhomboid family proteases. The increase in phosphorylation of extracellular signal which paralleled the temporal pattern of increased sleep was due to the overexpression of Rho and Star. Meanwhile, it is claimed that the production of EGFR ligand and PI neurons which activated ERK in tritocerebrum neurons is responsible in enhancing sleep.