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The effect of turtle (Trachemys scripta elegans) shell extract in normal and cyclophosphamide-treated mice.
- Source :
-
Food & Agricultural Immunology . Apr2007, Vol. 18 Issue 2, p83-93. 11p. 1 Chart, 6 Graphs. - Publication Year :
- 2007
-
Abstract
- In the present study, the immune effect of turtle shell extract on normal and cyclophosphamide (CP)-treated mice was determined. Mice treated with the turtle shell extract and CP had significantly (p<0.05) elevated levels of serum IgG, ATL, ATS and CREA compared with CP-treated mice. The turtle shell extract-treated mice had significantly elevated serum IgG (p<0.001), reduced serum CREA level (p<0.05), but the serum ATL, ATS and BUN did not change significantly compared with normal mice. Treatment with the turtle shell extract significantly improved the CD3+, CD4+CD8-, CD4-CD8+ and CD4+CD8+ cells percentages (p<0.05) in normal mice, and also significantly improved CD3+ and CD4+CD8- cells percentages in CP-treated mice (p<0.05). There was significant difference (p<0.001) in the proliferation rate of PHA-stimulated spleen lymphocyte in vitro between the turtle shell extract + CP-treated mice and CP-treated mice, and also between the turtle shell extract-treated mice and normal mice (p<0.05). These results demonstrate that the turtle shell extract can up-regulate the immune states of normal and CP-treated mice, and shows some protective effect on liver and kidney damage in CP-induced mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09540105
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Food & Agricultural Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26548192
- Full Text :
- https://doi.org/10.1080/09540100701327781