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Movement and mood disorder in two brothers with Gaucher disease.
- Source :
-
Clinical Genetics . Oct2007, Vol. 72 Issue 4, p357-361. 5p. - Publication Year :
- 2007
-
Abstract
- Gaucher disease (GD) is a lysosomal storage disorder with a wide spectrum of phenotypic presentations. We report the case histories of two adult brothers with GD who developed both parkinsonism and psychiatric symptoms. Direct sequencing and real-time polymerase chain reaction were used to establish that the patients were homozygous for mutation L444P. While parkinsonism has been described previously in GD, these patients had atypical features, including a complicated mood disorder. The comorbidity of GD and a mood disorder is a new finding, as psychiatric manifestations of GD have been described rarely. The etiology of the mental illness could be related to the processes contributing to the development of parkinsonism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099163
- Volume :
- 72
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Clinical Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 26516765
- Full Text :
- https://doi.org/10.1111/j.1399-0004.2007.00863.x