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Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy
- Source :
-
American Journal of Surgery . Oct2007, Vol. 194 Issue 4, p527-531. 5p. - Publication Year :
- 2007
-
Abstract
- Abstract: Background: Mucinous, medullary, and tubular carcinomas are uncommon types of breast cancer whose rarity does not permit large single-institution studies or randomized trials to define optimal treatments. In this study, we evaluated the long-term outcomes of breast-conserving therapy (BCT) for these subtypes of breast cancer and compared them with those for invasive ductal carcinoma. Methods: In our institutional database of patients who received BCT from 1965 to 1999, 1,643 patients with stage I to II mucinous (61), medullary (37), tubular (60), and invasive ductal (1,485) histologies were identified. The clinical and pathologic features of the 4 groups were evaluated and compared with respect to local-regional recurrence rates, disease-free survival, and overall survival (OS). Results: No statistically significant differences were found in the local-regional failure rate among the 4 groups (10.6-year median follow-up). Only patients with tubular carcinoma had better 5- and 10-year OS rates (P = .013). In multivariable analysis, factors associated with improved OS included age at or below 50 years, negative nodal status, use of chemotherapy or hormonal therapy, and tubular histology. Conclusions: BCT for mucinous, medullary, or tubular carcinoma resulted in similar local-regional failure rates to that for invasive ductal carcinoma. Tubular carcinoma patients had the most favorable OS. BCT is an appropriate treatment strategy for early-stage mucinous, medullary, and tubular carcinomas. [Copyright &y& Elsevier]
- Subjects :
- *BREAST cancer
*CANCER treatment
*CANCER in women
*LUMPECTOMY
Subjects
Details
- Language :
- English
- ISSN :
- 00029610
- Volume :
- 194
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- American Journal of Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 26491927
- Full Text :
- https://doi.org/10.1016/j.amjsurg.2007.06.012