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An open multicenter phase II trial of docetaxel–gemcitabine in Charlson score and performance status (PS) selected elderly patients with stage IIIB pleura/IV non-small-cell lung cancer (NSCLC): The GFPC 02-02a study
- Source :
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Critical Reviews in Oncology/Hematology . Oct2007, Vol. 64 Issue 1, p73-81. 9p. - Publication Year :
- 2007
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Abstract
- Abstract: The aim of this study was to determine the impact of patient selection based on age, comorbidity and performance status on the efficacy of platinum-free combination therapy on non-small-cell lung cancer after 65 years of age. We analyzed the overall response rate, the median survival time, the 1-year survival rate, toxicity and quality of life after one to three 6-week cycles of docetaxel 30mg/m2 weekly and gemcitabine 900mg/m2 at weeks 1, 2, 4 and 5. Fifty patients (median age 73.7 years) were eligible. The mean number of comorbid conditions per patient was 0.8 [Balducci L. Lung cancer and aging. ASCO 2005. Educational book. p. 587–91; Piquet J, Blanchon F, Grivaux M, et al. Primary bronchial carcinoma in elderly subjects in France. Rev Mal Respir 2003;20:691–9; Jatoi A, Hillman S, Stella P, et al. Should elderly non-small-cell lung cancer patients be offered elderly-specific trials? Results of a pooled analysis from the North Central Cancer Treatment Group. J Clin Oncol 2005;23:9113–9; Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist 2000;5:224–37]. Forty-five patients were assessable: 17 (34%) had an objective response, 18 (36%) had stable disease and 10 progressed (20%). The median survival time was 7 months and the 1-year survival rate 23.5%. The main grade III–IV adverse event was neutropenia (32% of patients). Conclusion: Platinum-free dual-agent chemotherapy gives similar results in patients over 65, selected on the basis of their precise age and comorbidity, to that reported in younger subjects. [Copyright &y& Elsevier]
- Subjects :
- *LUNG cancer
*OLDER people
*COMORBIDITY
*DRUG therapy
Subjects
Details
- Language :
- English
- ISSN :
- 10408428
- Volume :
- 64
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Critical Reviews in Oncology/Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 26488679
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2007.06.008