Spinal epidural Rosai–Dorfman disease preceding by relapsing uveitis: a case report with literature review.

Study design:Case report.Setting:Tertiary referral center hospital in Taiwan.Objectives:To report a case of spinal Rosai–Dorfman disease (RDD) presenting with paraparesis and also preceding by relapsing uveitis for 6 months. A thoracic laminectomy was performed to remove the solid mass. The pathological diagnosis reveals infiltrating histiocytes, emperipolesis and positivity for S-100. There is no recurrence 1 year later with MR imaging.Conclusions:The relapsing idiopathic uveitis may be a prodrome for this unusual disease, because RDD is associated closely to defective immunogical response. Early and accurate diagnosis of CNS RDD may reverse the neurologic deficits by early decompression.Spinal Cord (2007) 45, 641–644; doi:10.1038/sj.sc.3102006; published online 16 January 2007 [ABSTRACT FROM AUTHOR]