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Human C-Reactive Protein Binds Activating Fcγ Receptors and Protects Myeloma Tumor Cells from Apoptosis
- Source :
-
Cancer Cell . Sep2007, Vol. 12 Issue 3, p252-265. 14p. - Publication Year :
- 2007
-
Abstract
- Summary: Elevated levels of C-reactive protein (CRP) are present in many disease situations including malignancies and may contribute to the pathogenesis of cardiovascular disorders. This study was undertaken in a myeloma setting to determine whether CRP affects tumor cell growth and survival. We show that CRP enhanced myeloma cell proliferation under stressed conditions and protected myeloma cells from chemotherapy drug-induced apoptosis in vitro and in vivo. CRP binds activating Fcγ receptors; activates PI3K/Akt, ERK, and NF-κB pathways; and inhibits caspase cascade activation induced by chemotherapy drugs. CRP also enhanced myeloma cell secretion of IL-6 and synergized with IL-6 to protect myeloma cells from chemotherapy drug-induced apoptosis. Thus, our results implicate CRP as a potential target for cancer treatment. [Copyright &y& Elsevier]
- Subjects :
- *C-reactive protein
*DRUG therapy
*CELL proliferation
*APOPTOSIS
*CANCER
Subjects
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 12
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 26413382
- Full Text :
- https://doi.org/10.1016/j.ccr.2007.08.008